Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep579 | Pituitary and Neuroendocrinology | ECE2020

Once-weekly somapacitan in japanese adults with growth hormone deficiency was well tolerated, with similar efficacy to daily growth hormone: A randomised trial

Otsuka Fumio , Takahashi Yutaka , Tahara Shigeyuki , Ogawa Yoshihisa , Højby Rasmussen Michael , Takano Koji

Somapacitan is a long-acting, reversible albumin-binding growth hormone (GH) derivative. The objective of this trial was to evaluate the safety, efficacy and treatment satisfaction of onceweekly somapacitan versus daily GH (Norditropin) over 52 weeks in Japanese patients with adult GH deficiency (AGHD). This was a phase 3, multicentre, randomised, open-label, parallel-group, active-controlled trial (NCT03075644). Patients previously treated with GH were randomised 1:3 to daily...

ea0021p322 | Reproduction | SFEBES2009

Interaction between fibroblast growth factor-8 and bone morphogenetic proteins in regulation of ovarian steroidogenesis by rat granulosa cells

Miyoshi Tomoko , Otsuka Fumio , Yamashita Misuzu , Inagaki Kenichi , Suzuki Jiro , Makino Hirofumi

Bone morphogenetic proteins (BMPs) have been recognized as crucial molecules as a luteinizing factor but BMPs have differential actions in FSH-induced estradiol production in a ligand-dependent manner. We recently reported the presence of oocyte–granulosa cell communication through BMP actions by regulating MAPK. To approach the oocyte factors that modulate steroidogenesis controlled by BMPs, we here investigated the effects of FGF-8 in rat granulosa/oocyte co-cultures. F...

ea0021p123 | Cytokines and growth factors | SFEBES2009

Interaction of endothelin, aldosterone and bone morphogenetic proteins on mitotic actions of pulmonary arterial smooth muscle cells isolated from pulmonary arterial hypertension

Otsuka Fumio , Yamanaka Ryutaro , Nakamura Kazufumi , Yamashita Misuzu , Takeda Masaya , Suzuki Jiro , Miyoshi Tomoko , Inagaki Kenichi , Makino Hirofumi

Primary arterial hypertension (PAH) is a life-threatening disease that has prevalence of 1 to 2 occurrences per one million individuals. This disease is characterized by excessive proliferation of vascular endothelium and smooth muscle cells, causing thickening the walls of pulmonary arterioles. Recent studies have uncovered a link between familial and idiopathic PAH to BMPRII mutations. The pathology of PAH is characterized by the remodeling of pulmonary arteries due to pulmo...